Study on the decomposition products of thiadiazinthione and their anticancer properties

R Pérez; H Rodríguez; E Pérez; M Suárez; O Reyes; L J González; A López de Cerain; O Ezpelata; C Pérez; C Ochoa

doi:10.1055/s-0031-1300301

Study on the decomposition products of thiadiazinthione and their anticancer properties

Arzneimittelforschung. 2000 Sep;50(9):854-7. doi: 10.1055/s-0031-1300301.

Authors

R Pérez¹, H Rodríguez, E Pérez, M Suárez, O Reyes, L J González, A López de Cerain, O Ezpelata, C Pérez, C Ochoa

Affiliation

¹ Laboratorio de Síntesis Orgánica, Facultad de Qímica, Universidad de La Habana, Cuba.

PMID: 11050705
DOI: 10.1055/s-0031-1300301

Abstract

Study of the anticancer properties of thirty-four 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives has been carried out by using cytotoxicity assays against HeLa, HT-29 and Hep G2 cells. The decomposition products of thiadiazinthione 1 m have been studied and their anticancer properties evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Cell Survival / drug effects
Drug Screening Assays, Antitumor
HT29 Cells
HeLa Cells
Humans
Liver Neoplasms, Experimental / drug therapy
Thiadiazines / chemistry*
Thiadiazines / pharmacology*
Thiones / chemistry*
Thiones / pharmacology

Substances

Antineoplastic Agents
Thiadiazines
Thiones