PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages

M Martin; N Serradji; N Dereuddre-Bosquet; G Le Pavec; G Fichet; A Lamouri; F Heymans; J J Godfroid; P Clayette; D Dormont

doi:10.1128/AAC.44.11.3150-3154.2000

PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages

Antimicrob Agents Chemother. 2000 Nov;44(11):3150-4. doi: 10.1128/AAC.44.11.3150-3154.2000.

Authors

M Martin¹, N Serradji, N Dereuddre-Bosquet, G Le Pavec, G Fichet, A Lamouri, F Heymans, J J Godfroid, P Clayette, D Dormont

Affiliation

¹ CEA, Service de Neurovirologie, DSV/DRM, CRSSA, EPHE, Institut Paris-Sud sur les Cytokines, Fontenay aux Roses, France.

Abstract

We assessed the anti-human immunodeficiency virus (anti-HIV) activity in vitro of new platelet-activating factor (PAF) receptor antagonists, as PAF and viral replication are thought to be involved in HIV neuropathogenesis. We found that PMS-601 inhibited proinflammatory cytokine synthesis and HIV replication in macrophages and potentiated the antiretroviral activity of zidovudine. These results suggest that PMS-601 is of potential value as an adjuvant treatment for HIV infection.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / pharmacology*
Drug Synergism
HIV / drug effects*
HIV / physiology
Humans
Macrophages / drug effects
Macrophages / virology*
Piperazines / pharmacology*
Platelet Membrane Glycoproteins / antagonists & inhibitors*
Receptors, Cell Surface*
Receptors, G-Protein-Coupled*
Virus Replication / drug effects
Zidovudine / pharmacology

Substances

Anti-HIV Agents
PMS 601
Piperazines
Platelet Membrane Glycoproteins
Receptors, Cell Surface
Receptors, G-Protein-Coupled
platelet activating factor receptor
Zidovudine