Hydrolysis of lysergamide to lysergic acid by Rhodococcus equi A4

J Biotechnol. 2001 Nov 17;84(1):63-6. doi: 10.1016/s0168-1656(00)00332-1.

Abstract

From a mixture of lysergamide and its epimer isolysergamide, Rhodococcus equi A4 containing amidase preferentially hydrolyzed lysergamide into lysergic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amidohydrolases / metabolism*
  • Biotechnology / methods
  • Chromatography, High Pressure Liquid
  • Claviceps / enzymology
  • Ergonovine / metabolism
  • Hydrolysis
  • Lysergic Acid / chemistry
  • Lysergic Acid / metabolism*
  • Lysergic Acid Diethylamide / analogs & derivatives*
  • Lysergic Acid Diethylamide / chemistry
  • Lysergic Acid Diethylamide / metabolism*
  • Rhodococcus equi / enzymology*
  • Stereoisomerism

Substances

  • lysergamide
  • lysergic acid alpha-hydroxyethylamide
  • Lysergic Acid Diethylamide
  • Amidohydrolases
  • Lysergic Acid
  • Ergonovine