Total synthesis of (-)-ascochlorin via a cyclobutenone-based benzannulation strategy

Org Lett. 2000 Oct 19;2(21):3407-10. doi: 10.1021/ol006561c.

Authors

G B Dudley¹, K S Takaki, D D Cha, R L Danheiser

Affiliation

¹ Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

PMID: 11029223
DOI: 10.1021/ol006561c

Abstract

The application of a convergent benzannulation strategy in an efficient synthesis of (-)-ascochlorin is described.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Alkenes / chemical synthesis*
Cyclobutanes / chemistry*
Phenols / chemical synthesis*
Stereoisomerism

Substances

Alkenes
Cyclobutanes
Phenols
ascochlorin

Grants and funding