Abstract
Beditin, or 2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride, is a new benzodioxane derivative possessing antihypoxant and alpha 2-adrenoreceptor blocker properties. In contrast to idazoxan, a well-known alpha 2-adrenoreceptor blocker, beditin (3 mg/kg) significantly increases the circulation rate and decreases the blood vessel resistance in various brain structures of rats and cats without considerably changing their systemic hemodynamic indices. Upon a one-side ligation of the common carotid artery in rats, beditin prevented a sharp increase in the lactate dehydrogenase activity and a growth in the content of free ammonia in the brain, which are characteristic of the ischemic states. The ammonia-eliminating effect of beditin is related to an increase in the glutamate dehydrogenase activity in the reductive amination reaction.
MeSH terms
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Adrenergic alpha-Antagonists / pharmacology*
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Animals
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Blood Flow Velocity / drug effects
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Brain / blood supply
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Brain / enzymology
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Brain / metabolism*
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Cats
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Cerebrovascular Circulation / drug effects*
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Dioxanes / pharmacology*
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Glutamate Dehydrogenase / metabolism
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Hypoxia / prevention & control
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Hypoxia-Ischemia, Brain / metabolism
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Hypoxia-Ischemia, Brain / physiopathology
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Hypoxia-Ischemia, Brain / prevention & control
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L-Lactate Dehydrogenase / metabolism
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Male
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Muscle, Skeletal / blood supply
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Muscle, Skeletal / metabolism
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Rats
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Rats, Wistar
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Receptors, Adrenergic, alpha-2 / drug effects*
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Skin / blood supply
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Skin / metabolism
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Thiazoles / pharmacology*
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Vascular Resistance / drug effects
Substances
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Adrenergic alpha-Antagonists
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Dioxanes
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Receptors, Adrenergic, alpha-2
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Thiazoles
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beditine
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L-Lactate Dehydrogenase
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Glutamate Dehydrogenase