Abstract
This retrospective observational intravascular ultrasound study evaluated whether simvastatin therapy limits lumen area reduction 1-year after percutaneous transluminal angioplasty (PTA) by reducing reactive plaque growth, reducing reactive vasoconstriction, or both. This study showed that plaque growth is a general response 1 year after PTA regardless of the use of simvastatin; simvastatin has the potential to induce positive vascular remodeling, thereby reducing the occurrence of restenosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Angioplasty, Balloon, Coronary*
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Arterial Occlusive Diseases / diagnostic imaging
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Arterial Occlusive Diseases / drug therapy
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Arterial Occlusive Diseases / pathology
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Arterial Occlusive Diseases / therapy*
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Chemotherapy, Adjuvant
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Female
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Femoral Artery* / diagnostic imaging
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Femoral Artery* / pathology
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Follow-Up Studies
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
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Male
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Middle Aged
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Popliteal Artery* / diagnostic imaging
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Popliteal Artery* / pathology
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Retrospective Studies
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Simvastatin / therapeutic use*
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Ultrasonography, Interventional
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Simvastatin