Isolation and characterization of adenovirus 5 from the brain of an infant with fatal cerebral edema

Clin Infect Dis. 2000 Sep;31(3):830-3. doi: 10.1086/314041.

Abstract

This report describes a fatal case of cerebral edema caused by adenovirus in a previously healthy 18-month-old infant who developed skin rash, pulmonary congestion, and fever and who died 6 days later. Adenovirus hexon gene sequences were detected in brain tissue and brain tissue cultures. The virus was typed as adenovirus 5.

Publication types

  • Case Reports

MeSH terms

  • Adenovirus Infections, Human / complications
  • Adenovirus Infections, Human / virology*
  • Adenoviruses, Human / genetics
  • Adenoviruses, Human / isolation & purification*
  • Adenoviruses, Human / ultrastructure
  • Base Sequence
  • Brain / ultrastructure
  • Brain / virology*
  • Brain Edema / complications
  • Brain Edema / pathology*
  • DNA, Viral / genetics
  • Fatal Outcome
  • Humans
  • Infant
  • Male
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sequence Homology, Nucleic Acid
  • Tumor Cells, Cultured

Substances

  • DNA, Viral