Humoral immune responses to chicken infectious anemia virus in three strains of chickens in a closed flock

Avian Dis. 2000 Jul-Sep;44(3):661-7.

Abstract

This is a comparative study on seroconversion to chicken infectious anemia virus (CIAV) in a closed flock of specific-pathogen-free chickens undergoing a natural outbreak and after vaccination of some of these flocks with a commercial, live vaccine. The N2a strain (B21B21 haplotype) had the highest seroconversion after natural infection (94%) or vaccination (100%), followed by the P2a strain (B19B19) at 75%-82% seroconversion after natural infection and 85% seroconversion after vaccination. The S13 (B13B13) chickens were 26% seropositive after natural infection and 75% seropositive after vaccination. N2a chickens with polymerase chain reaction (PCR)-positive tissues were 97% seropositive compared to 80%-83% PCR-positive and seropositive for the P2a chickens and only 8% seropositive and PCR-positive for the S13 chickens. Seroconversion occurred at or near sexual maturity after natural infection in seven flocks studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Husbandry
  • Animals
  • Antibodies, Viral / blood*
  • Antibody Formation
  • Chicken anemia virus / immunology*
  • Chicken anemia virus / isolation & purification
  • Chickens / immunology*
  • Circoviridae Infections / epidemiology
  • Circoviridae Infections / immunology
  • Circoviridae Infections / prevention & control
  • Circoviridae Infections / veterinary*
  • Disease Outbreaks / veterinary
  • Polymerase Chain Reaction
  • Poultry Diseases / epidemiology
  • Poultry Diseases / immunology*
  • Poultry Diseases / prevention & control
  • Species Specificity
  • Specific Pathogen-Free Organisms
  • Time Factors
  • Viral Vaccines*

Substances

  • Antibodies, Viral
  • Viral Vaccines