Functional properties of regenerating skeletal muscle following LIF administration

P Gregorevic; A Hayes; G S Lynch; D A Williams

doi:10.1002/1097-4598(200010)23:10<1586::aid-mus17>3.0.co;2-a

Functional properties of regenerating skeletal muscle following LIF administration

Muscle Nerve. 2000 Oct;23(10):1586-8. doi: 10.1002/1097-4598(200010)23:10<1586::aid-mus17>3.0.co;2-a.

Authors

P Gregorevic¹, A Hayes, G S Lynch, D A Williams

Affiliation

¹ Department of Physiology, The University of Melbourne, Victoria 3010, Australia.

PMID: 11003796
DOI: 10.1002/1097-4598(200010)23:10<1586::aid-mus17>3.0.co;2-a

Abstract

We tested the hypothesis that periodic systemic administration of the myogenic cytokine leukemia inhibitory factor (LIF) enhances the functional recovery of regenerating skeletal muscle following bupivacaine-induced degeneration. LIF had no effect on functional capacity or regenerating myofiber size in rat muscles at 7, 14, or 21 days post-injury. The results do not support exogenous administration of LIF as a treatment for acute muscle injury, but a more frequent dosing regimen should be tested.

MeSH terms

Animals
Growth Inhibitors / pharmacology*
Interleukin-6*
Leukemia Inhibitory Factor
Lymphokines / pharmacology*
Male
Muscles / drug effects*
Muscles / physiopathology*
Muscular Diseases / physiopathology*
Rats
Rats, Sprague-Dawley
Regeneration / drug effects*
Regeneration / physiology*

Substances

Growth Inhibitors
Interleukin-6
Leukemia Inhibitory Factor
Lymphokines