Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast

Thorax. 2000 Oct;55 Suppl 2(Suppl 2):S28-31. doi: 10.1136/thorax.55.suppl_2.s28.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / drug therapy
  • Asthma / genetics*
  • Asthma / physiopathology
  • Cysteine / biosynthesis*
  • Eosinophils / metabolism
  • Female
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Indoles
  • Leukotriene Antagonists / therapeutic use
  • Leukotrienes / biosynthesis*
  • Male
  • Middle Aged
  • Phenylcarbamates
  • Prognosis
  • Respiratory Mechanics / drug effects
  • Sulfonamides
  • Tosyl Compounds / therapeutic use*

Substances

  • Anti-Asthmatic Agents
  • Indoles
  • Leukotriene Antagonists
  • Leukotrienes
  • Phenylcarbamates
  • Sulfonamides
  • Tosyl Compounds
  • cysteinyl-leukotriene
  • Glutathione Transferase
  • leukotriene-C4 synthase
  • Cysteine
  • zafirlukast