Abstract
We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B. This in vitro antagonism was reversible.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / antagonists & inhibitors
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Amphotericin B / pharmacology*
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Antifungal Agents / antagonists & inhibitors
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Antifungal Agents / pharmacology*
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Aspergillus fumigatus / drug effects*
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Drug Interactions
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Itraconazole / antagonists & inhibitors
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Itraconazole / pharmacology*
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Microbial Sensitivity Tests
Substances
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Antifungal Agents
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Itraconazole
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Amphotericin B