Abstract
Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericin B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / therapeutic use
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Animals
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Antifungal Agents / therapeutic use*
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Aspergillosis / drug therapy*
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Aspergillosis / microbiology
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Aspergillus fumigatus / drug effects
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Fluocinolone Acetonide / pharmacology
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Glucocorticoids / pharmacology
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Guinea Pigs
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Immunocompromised Host
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Immunosuppressive Agents / pharmacology
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Male
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Organ Culture Techniques
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Pyrimidines / therapeutic use*
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Triazoles / therapeutic use*
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Voriconazole
Substances
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Antifungal Agents
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Glucocorticoids
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Immunosuppressive Agents
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Pyrimidines
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Triazoles
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Fluocinolone Acetonide
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Amphotericin B
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Voriconazole