Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil

I R Baxendale; S V Ley

doi:10.1016/s0960-894x(00)00383-8

Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil

Bioorg Med Chem Lett. 2000 Sep 4;10(17):1983-6. doi: 10.1016/s0960-894x(00)00383-8.

Authors

I R Baxendale¹, S V Ley

Affiliation

¹ Department of Chemistry, University of Cambridge, UK.

PMID: 10987432
DOI: 10.1016/s0960-894x(00)00383-8

Abstract

Sildenafil 1 (Viagra), a well known and commercially important pharmaceutical drug, has been prepared using polymer-supported reagents in a multi-step, convergent process resulting in a clean and efficient preparation without the need for conventional purification methods.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Indicators and Reagents
Phosphodiesterase Inhibitors / chemical synthesis*
Piperazines / chemical synthesis*
Purines
Sildenafil Citrate
Sulfones

Substances

Indicators and Reagents
Phosphodiesterase Inhibitors
Piperazines
Purines
Sulfones
Sildenafil Citrate