The growth hormone (GH) receptor and binding protein are synthesized in the CNS and are regulated differentially to their hepatic counterparts. GH is also synthesized in the CNS and is regulated differentially to its hypophyseal counterpart. Insulin-like growth factor I (IGF-I) is synthesized in the CNS and in the early postnatal period is regulated by peripherally secreted GH. Both GH and IGF-I alter the size and morphology of the CNS during development and affect differentiated cell function in the CNS, with consequent modulation of cognitive function. Differential utilization of the same signal transduction molecules indicates that GH and IGF-I possess distinct overlapping roles in CNS function.