In the light of the similarity of the neurochemical mechanisms of behavior during ontogenesis and in adult organisms, studies were performed on the effects of antibodies to neurotrophic factors--S-100b protein, CSL lectin, and R1 lectin-on the acquisition, retention, and reproduction of habituated acoustic startle reactions and freezing behavior in adult rats. Antibodies against neurotrophic factors were found to have selective, dose-dependent effects on the types of behavior investigated. Antibodies to S-100b, CSL, and R1, at a dose of 5 microg, induced derangements in the processes of consolidation and/or retention of behavioral habits. At a dose of 2 microg, antibodies to S-100b selectively blocked the retention of long-term habituation of the startle reaction, while a dose of 0.5 microg had no such effect. Antibodies to neurotrophic factors had no effect on reproduction of acquired defensive habits.