Blood stem-cell transplantation for chronic active Epstein-Barr virus with lymphoproliferation

Lancet. 2000 Jul 15;356(9225):223-4. doi: 10.1016/S0140-6736(00)02488-0.

Abstract

A boy with chronic active Epstein-Barr virus infection (EBV) developed bilateral exophthalmos by infiltrating EBV-infected natural-killer cells during combined chemotherapy. This unusual presentation resolved completely after allogeneic bone-marrow transplantation, and EBV-infected peripheral T and natural-killer cells were also eradicated.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antiviral Agents / therapeutic use
  • Bone Marrow Transplantation
  • Child
  • Chronic Disease
  • Epstein-Barr Virus Infections / therapy*
  • Exophthalmos / virology
  • Glucocorticoids / therapeutic use
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Killer Cells, Natural / virology
  • Lymphoproliferative Disorders / therapy
  • Lymphoproliferative Disorders / virology*
  • Male
  • Oculomotor Muscles / virology
  • T-Lymphocytes / virology
  • Transplantation Conditioning
  • Transplantation, Homologous

Substances

  • Antiviral Agents
  • Glucocorticoids
  • Immunosuppressive Agents