The aim of the work was the examinations of antioxidant enzymatic activity in blood of patients with chronic hypertrophic of maxillary sinusitis (15 patients) and laryngitis (10 patients), and carcinoma of larynx (7 patients) in comparison with healthy persons (15). The enzymatic activity of superoxide dismutase in blood (method of Misra and Fridovich), katalase (method of Beers and Sizer) and malonyl dialdehyde (method of Placer) were evaluated. The obtained results pointed at significant reduction of antioxidant enzymatic activity against the oxygen species generation in blood of patients with chronic hypertrophic of maxillary sinusits and laryngitis and mainly with the carcinoma of larynx (in comparison with healthy persons). At the same patients observed the significant growth of peroxydation lipoid and disturbances of function of cells the human body.