NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival

Cytokine Growth Factor Rev. 2000 Dec;11(4):303-20. doi: 10.1016/s1359-6101(00)00009-5.

Abstract

The Rel/NF-kappaB family of transcription factors has been implicated in the regulation of genes involved in immune and inflammatory responses, and of processes such as cell survival, apoptosis, development, differentiation, cell growth and neoplastic transformation. In this report we will summarize recent findings which highlight critical roles of NF-kappaB in different processes in hematopoietic and neuronal cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • B-Lymphocytes / cytology
  • B-Lymphocytes / physiology
  • Cell Differentiation
  • Cell Survival
  • Dendritic Cells / cytology
  • Dendritic Cells / physiology
  • Hematopoiesis / physiology*
  • Humans
  • Mutation
  • NF-kappa B / genetics
  • NF-kappa B / physiology*
  • Nervous System Diseases / etiology
  • Neurons / cytology
  • Neurons / physiology*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / physiology

Substances

  • NF-kappa B