Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in human bone cell conditioned medium do not change with age

J Pfeilschifter; I Diel; T Klöppinger; H Bismar; E M Schuster; S Balbach; R Ziegler; D Baylink; S Mohan

doi:10.1016/s0047-6374(00)00132-9

Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in human bone cell conditioned medium do not change with age

Mech Ageing Dev. 2000 Aug 15;117(1-3):109-14. doi: 10.1016/s0047-6374(00)00132-9.

Authors

J Pfeilschifter¹, I Diel, T Klöppinger, H Bismar, E M Schuster, S Balbach, R Ziegler, D Baylink, S Mohan

Affiliation

¹ Kliniken Bergmannsheil, Department of Internal Medicine, University of Bochum, Bochum, Germany. johannes.pfeilschifter@ruhr-uni-bochum.de

PMID: 10958927
DOI: 10.1016/s0047-6374(00)00132-9

Abstract

We examined the effects of age on the secretion of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in long-term bone cell cultures from 71 female donors, aged 28-79 years. Our results suggest that under basal conditions, the intrinsic capacity of human bone cells to produce these IGF components is largely preserved with age.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aging / metabolism*
Cells, Cultured
Culture Media, Conditioned
Female
Humans
Ilium / cytology
Ilium / metabolism
Insulin-Like Growth Factor Binding Protein 4 / metabolism*
Insulin-Like Growth Factor Binding Protein 5 / metabolism*
Insulin-Like Growth Factor I / metabolism*
Insulin-Like Growth Factor II / metabolism*
Middle Aged

Substances

Culture Media, Conditioned
Insulin-Like Growth Factor Binding Protein 4
Insulin-Like Growth Factor Binding Protein 5
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II