Assignments of the tyrosinase related protein-1 and -2 genes to human chromosome bands 9p23 and 13q32.1 by in situ hybridization

Yonsei Med J. 2000 Jun;41(3):398-400. doi: 10.3349/ymj.2000.41.3.398.

Abstract

To determine the precise chromosomal localization of tyrosine related protein-1 and -2 (TRP-1 and TRP-2) genes by fluorescence in situ hybridization, we used DNAs isolated from human bacterial artificial chromosome clones. They contain genomic sequences with approximately 120 kb inserts for TRP-1 and TRP-2. The TRP-1 and TRP-2 genes were assigned to human chromosome bands 9p23 and 13q32.1, respectively. These results confirmed the previously mapped location for the TRP-1 gene and more precisely located the TRP-2 gene, which had previously been mapped to chromosome 13q31-q32.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 13 / genetics*
  • Chromosomes, Human, Pair 9 / genetics*
  • Gene Library
  • Humans
  • In Situ Hybridization, Fluorescence
  • Intramolecular Oxidoreductases / genetics*
  • Membrane Glycoproteins*
  • Oxidoreductases*
  • Proteins / genetics*

Substances

  • Membrane Glycoproteins
  • Proteins
  • Oxidoreductases
  • TYRP1 protein, human
  • tyrosinase-related protein-1
  • Intramolecular Oxidoreductases
  • dopachrome isomerase