We describe two cases in which right ventricular pacing produced severe hemodynamic deterioration and in which changing the pacing from the right to the left ventricle sharply corrected these alterations, while simultaneous biventricular pacing did not. Chronic left ventricular pacing can solve hemodynamic alterations in severe pacemaker syndromes, thereby avoiding the need for mitral prosthesis implantation in some cases. The use of this procedure today should be individualized, including acute hemodynamic and echocardiographic studies, because the width of the QRS complex during pacing is not a significant predictor of hemodynamic efficiency.