[Experimental models, of Parkinson disease]

Rev Neurol. 2000 Jul;31(1):60-6.
[Article in Spanish]

Abstract

This article reviews the most useful animal models of Parkinson's disease available. Basically they include the model of unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA) in rodents and the 1-methy-4-phenyl-1,2,3,6, tetrahydropyridine (MPTP) model of parkinsonism in non-human primates. The major neurochemical and histological alterations found in these two models are also analyzed. Finally, possible applications of these models of parkinsonism are also discussed.

Publication types

  • English Abstract
  • Review

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / adverse effects
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / metabolism
  • Animals
  • Corpus Striatum / drug effects
  • Disease Models, Animal*
  • Dopamine / metabolism
  • Humans
  • Monoamine Oxidase Inhibitors / pharmacology
  • Neurotoxins / metabolism
  • Oxidative Stress / drug effects
  • Oxidopamine / adverse effects
  • Oxidopamine / metabolism
  • Parkinson Disease / etiology*
  • Rats
  • Substantia Nigra / drug effects

Substances

  • Monoamine Oxidase Inhibitors
  • Neurotoxins
  • Oxidopamine
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Dopamine