Abstract
This article reviews the most useful animal models of Parkinson's disease available. Basically they include the model of unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA) in rodents and the 1-methy-4-phenyl-1,2,3,6, tetrahydropyridine (MPTP) model of parkinsonism in non-human primates. The major neurochemical and histological alterations found in these two models are also analyzed. Finally, possible applications of these models of parkinsonism are also discussed.
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / adverse effects
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / metabolism
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Animals
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Corpus Striatum / drug effects
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Disease Models, Animal*
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Dopamine / metabolism
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Humans
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Monoamine Oxidase Inhibitors / pharmacology
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Neurotoxins / metabolism
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Oxidative Stress / drug effects
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Oxidopamine / adverse effects
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Oxidopamine / metabolism
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Parkinson Disease / etiology*
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Rats
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Substantia Nigra / drug effects
Substances
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Monoamine Oxidase Inhibitors
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Neurotoxins
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Oxidopamine
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Dopamine