Synthetic spider silk: a modular fiber

Trends Biotechnol. 2000 Sep;18(9):374-9. doi: 10.1016/s0167-7799(00)01481-5.

Abstract

Spiders make their webs and perform a wide range of tasks with up to seven different types of silk fiber. These different fibers allow a comparison of structure with function, because each silk has distinct mechanical properties and is composed of peptide modules that confer those properties. By using genetic engineering to mix the modules in specific proportions, proteins with defined strength and elasticity can be designed, which have many potential medical and engineering uses.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amino Acid Motifs / genetics
  • Amino Acid Sequence
  • Animals
  • DNA, Complementary / chemical synthesis
  • Genes, Synthetic
  • Molecular Sequence Data
  • Protein Biosynthesis
  • Proteins / chemical synthesis*
  • Proteins / chemistry*
  • Proteins / genetics
  • Repetitive Sequences, Amino Acid
  • Spiders / chemistry*
  • Spiders / genetics

Substances

  • DNA, Complementary
  • FLAG protein, Nephila
  • Proteins