Hypoglycemic effects of lactucin-8-O-methylacrylate of Parmentiera edulis fruit

R M Perez; C Perez; M A Zavala; S Perez; H Hernandez; F Lagunes

doi:10.1016/s0378-8741(99)00212-3

Hypoglycemic effects of lactucin-8-O-methylacrylate of Parmentiera edulis fruit

J Ethnopharmacol. 2000 Aug;71(3):391-4. doi: 10.1016/s0378-8741(99)00212-3.

Authors

R M Perez¹, C Perez, M A Zavala, S Perez, H Hernandez, F Lagunes

Affiliation

¹ Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingeniería Química e Industias extractivas IPN, Punto fijo 16, col, cp 07708, Torres Lindavista, Mexico. dmex@df1.telmex.net.mx

PMID: 10940575
DOI: 10.1016/s0378-8741(99)00212-3

Abstract

Hypoglycemic activity-guided fractionation together with chemical analysis led to the isolation of one guaianolide (lactucin-8-O-methylacrylate) from the chloroform extract of the dried fruits of Parmentiera edulis. Identification was based on spectroscopic methods. The compounds lowers blood sugar levels after administration to alloxan-diabetic mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alloxan
Animals
Diabetes Mellitus, Experimental / drug therapy
Hypoglycemic Agents / chemistry*
Hypoglycemic Agents / pharmacology
Magnetic Resonance Spectroscopy
Methacrylates / chemistry
Mice
Plants, Medicinal / chemistry*

Substances

Hypoglycemic Agents
Methacrylates
lactucin-8-O-methylacrylate
Alloxan