A patient with cyclic neutropenia complicated by severe persistent neutropenia successfully delivered a healthy baby

Intern Med. 2000 Aug;39(8):663-6. doi: 10.2169/internalmedicine.39.663.

Abstract

We describe a 24-year-old pregnant woman complicated by cyclic neutropenia (CN), who was successfully treated with granulocyte-colony stimulating factor (G-CSF). Her white blood cell (WBC) and neutrophil count fluctuated from 2,600 to 4,600/microl, and 26 to 2,530/microl, respectively. The peak neutrophil count gradually decreased as pregnancy advanced, resulting in the disappearance of its cyclicity. At 39 weeks of pregnancy when the neutrophil count became 84/microl, the patient was started on G-CSF and her neutrophil count increased to 1,550/microl on the fourth day after delivery. She delivered a healthy baby without any complications at 39 weeks of pregnancy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Female
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Infant, Newborn
  • Leukocyte Count
  • Male
  • Neutropenia / blood
  • Neutropenia / complications*
  • Neutropenia / drug therapy
  • Neutrophils
  • Pregnancy
  • Pregnancy Complications, Hematologic* / blood
  • Pregnancy Complications, Hematologic* / drug therapy
  • Pregnancy Outcome

Substances

  • Granulocyte Colony-Stimulating Factor