Vinylpyrrolidone/vinylacetate copolymer (VP/VAc) was used for the enhancement of dissolution rate of carbamazepine, an antiepileptic drug characterized by very low water solubility. Microspheres containing different drug-to-polymer ratios were prepared using a solvent-evaporation technique and their physical characterizations were carried out by differential scanning calorimetry, x-ray diffractometry, and scanning electron microscopy. Through the solubilization kinetics and dissolution rates studies, the in vitro drug availability of the microspheres was evaluated. These results showed that the dissolution of carbamazepine in gastrointestinal fluids from all of the prepared formulations was increased with respect to the drug itself. However, the best dissolution parameters were obtained from 1:10 w/w system because of the presence of the drug in amorphous form and its efficient encapsulation.