Abstract
Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 micrograms/mL respectively.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chromatography, High Pressure Liquid
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Humans
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Magnetic Resonance Spectroscopy
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Mice
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Peru
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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Tumor Cells, Cultured
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Ursolic Acid
Substances
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2-oxopomolic acid
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3-O-acetylpomolic acid
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Antineoplastic Agents, Phytogenic
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Triterpenes
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pomolic acid
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Oleanolic Acid