Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa

Planta Med. 2000 Jun;66(5):483-4. doi: 10.1055/s-2000-8583.

Abstract

Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 micrograms/mL respectively.

Publication types

  • Letter

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Chromatography, High Pressure Liquid
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Oleanolic Acid / analogs & derivatives
  • Oleanolic Acid / chemistry
  • Oleanolic Acid / isolation & purification
  • Oleanolic Acid / pharmacology
  • Peru
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Tumor Cells, Cultured
  • Ursolic Acid

Substances

  • 2-oxopomolic acid
  • 3-O-acetylpomolic acid
  • Antineoplastic Agents, Phytogenic
  • Triterpenes
  • pomolic acid
  • Oleanolic Acid