Mapping of the N terminus of the Schistosoma mansoni tegumental antigen Sm15 to its predicted precursor protein

Int J Parasitol. 2000 Jun;30(7):859-61. doi: 10.1016/s0020-7519(00)00069-2.

Abstract

Sm15 is a major Schistosoma mansoni 15 kDa tegumental antigen, resulting from the proteolytic processing of a larger precursor. The amino terminus of Sm15 was identified by direct amino acid sequencing, and the antigen was tentatively mapped to the segment spanning amino acids 362-497 of the precursor. This will allow subsequent studies to elucidate the possible immunological role of proteolytic processing in schistosomiasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Protozoan / chemistry*
  • Blotting, Western
  • Cloning, Molecular
  • DNA, Protozoan / chemistry
  • Epitope Mapping
  • Molecular Sequence Data
  • Protein Precursors / chemistry*
  • Schistosoma mansoni / chemistry*
  • Schistosoma mansoni / immunology
  • Sequence Analysis, Protein

Substances

  • Antigens, Protozoan
  • DNA, Protozoan
  • Protein Precursors