Abstract
Plasma and cerebrospinal fluid (CSF) indinavir concentrations were measured by high-performance liquid chromatography. The median concentration in plasma exceeded that in CSF 10-fold. The modeled CSF curve was flat at 155 nM, and the estimated ratio of the areas under the CSF and plasma concentration-time curves was 6%. We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Chromatography, High Pressure Liquid
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HIV Infections / blood
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HIV Infections / cerebrospinal fluid
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HIV Infections / metabolism*
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HIV Protease Inhibitors / blood
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HIV Protease Inhibitors / cerebrospinal fluid
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HIV Protease Inhibitors / pharmacokinetics*
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Humans
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Indinavir / blood
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Indinavir / cerebrospinal fluid
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Indinavir / pharmacokinetics*
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Male
Substances
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HIV Protease Inhibitors
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Indinavir