Protracted febrile myalgia of familial Mediterranean fever. Mutation analysis and clinical correlations

Scand J Rheumatol. 2000;29(3):174-6. doi: 10.1080/030097400750002058.

Abstract

Protracted febrile myalgia (PFM) is a rare form of vasculitic disease that affects patients with familial Mediterranean fever (FMF). Mutation analysis performed in 15 patients who suffered from this disorder showed that 9 of the 15 patients were homozygous for M694V. FMF in these 9 patients was associated with more severe symptoms compared to a group of 30 M694V homozygous FMF patients without PFM.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cytoskeletal Proteins
  • DNA Mutational Analysis*
  • Familial Mediterranean Fever / genetics*
  • Female
  • Fever / genetics*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Muscular Diseases / genetics*
  • Mutation*
  • Polymerase Chain Reaction
  • Proteins / genetics*
  • Pyrin

Substances

  • Cytoskeletal Proteins
  • MEFV protein, human
  • Proteins
  • Pyrin