Risk factors predictive of methicillin-resistant Staphylococcus aureus (MRSA) colonization in 786 of 910 nursing home residents were evaluated. A customized questionnaire was completed by theresidents, who were screened for MRSA. The risk factors significantly associated with MRSA colonization were male sex, age >80 years, residence in the nursing home for <six months, hospitalization during the previous 6 months, peripheral vascular disease, pressure sores, steroid therapy, poor general skin condition, antibiotic therapy during the previous three months and a mental test score of O14. Multivariate analysis identified male sex and pressure sores as independent variables.