Abstract
The regulatory function of a DNA fragment responsible for actinomycin resistance in the typed strain Streptomyces werraensis ATCC 1365, which produces a macrotetrolide antibiotic, was studied. Metabolic changes made this strain capable of producing an antibiotic complex, which comprises four biologically active compounds absent from the parent culture.
MeSH terms
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Anti-Bacterial Agents / biosynthesis*
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Bacterial Typing Techniques
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DNA, Bacterial / genetics
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Dactinomycin / pharmacology
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Drug Resistance, Microbial / genetics
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Macrolides
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Streptomyces / classification
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Streptomyces / drug effects
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Streptomyces / genetics
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Streptomyces / metabolism*
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Macrolides
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Dactinomycin