Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists

Bioorg Med Chem Lett. 2000 Jun 5;10(11):1203-5. doi: 10.1016/s0960-894x(00)00216-x.

Abstract

Quinazolin-4-one derivatives of methaqualone substituted at C-2 define a new class of noncompetitive antagonists at AMPA receptors.

MeSH terms

  • Animals
  • Cells, Cultured
  • Cerebellum / drug effects
  • Cerebellum / ultrastructure
  • Cytoplasmic Granules / drug effects
  • Excitatory Amino Acid Antagonists / chemistry
  • Excitatory Amino Acid Antagonists / pharmacology
  • Methaqualone / analogs & derivatives
  • Methaqualone / pharmacology*
  • Rats
  • Receptors, AMPA / antagonists & inhibitors*

Substances

  • Excitatory Amino Acid Antagonists
  • Receptors, AMPA
  • Methaqualone