Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives

Bioorg Med Chem Lett. 2000 Jun 5;10(11):1143-5. doi: 10.1016/s0960-894x(00)00130-x.

Abstract

The new cephalosporins having N-linked quarternary ammonium salt at C-3 position were prepared from the reaction of 2-methylimino-3-methyl-1,3-thiazoline derivatives with cephalosporins. Also antimicrobial activities of those compounds were determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Cephalosporins / chemical synthesis*
  • Cephalosporins / pharmacology*
  • Gram-Negative Bacteria / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Microbial Sensitivity Tests
  • Thiazoles / chemical synthesis*
  • Thiazoles / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Thiazoles