The debate surrounding the use of low-fat, high-carbohydrate diets has raised concerns regarding the atherogenicity of triglyceride-rich lipoproteins. A recent study has demonstrated that feeding a diet high in carbohydrate delays very low-density lipoprotein (VLDL) clearance. The same diet fed to mildly hyperinsulinemic subjects delays both VLDL and chylomicron clearance without affecting triglyceride production.