The results of surgical treatment of 96 patients with giant duodenal ulcer, to whom selective proximal vagotomy (SPV), duodenoplasty (DP), vagotomy with pylorus destroying operation (PDO), gastric resection were performed, were analyzed. Prophylactic methods for an acute postoperative pancreatitis (APP) occurrence before, during and after the operation performance were elaborated. It was established, that the frequency of APP occurrence after SPV and DP is lower than after gastric resection and vagotomy with PDO.