Non-electrostatic complexes with DNA: towards novel synthetic gene delivery systems

Bioorg Med Chem Lett. 2000 May 1;10(9):911-4. doi: 10.1016/s0960-894x(00)00118-9.

Abstract

We have developed new DNA complexing amphiphile based on Hoechst 33258 interaction with DNA grooves. The synthesis and physicochemical characterisation of lipid/DNA complexes, as compared to that of classical lipopolyamine for gene delivery, are described and discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bisbenzimidazole / chemistry*
  • Chemical Phenomena
  • Chemistry, Physical
  • DNA / chemistry*
  • DNA / genetics
  • Electrophoresis, Polyacrylamide Gel
  • Ethidium / chemistry
  • Fluorescent Dyes
  • Gene Transfer Techniques*
  • Genetic Vectors
  • Hydrogen Bonding
  • Lipids
  • Quaternary Ammonium Compounds / chemistry
  • Spectrophotometry, Ultraviolet

Substances

  • Fluorescent Dyes
  • Lipids
  • Quaternary Ammonium Compounds
  • DNA
  • Ethidium
  • Bisbenzimidazole