Abstract
A-25 sephadex-induced granulomatous inflammation of the lungs in rats was treated with beta-carotene and intal in inhalations. Both drugs showed antiinflammatory activity reducing the area of alveolitis and emphysema in the lungs, number of neutrophils and lymphocytes in the bronchoalveolar fluid. The experimental data allow to recommend further trial of intal and beta-carotene in granulomatous pulmonary diseases.
MeSH terms
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Animals
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Anti-Inflammatory Agents / therapeutic use*
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Bronchoalveolar Lavage Fluid / cytology
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Cromolyn Sodium / therapeutic use*
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Dextrans
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Disease Models, Animal*
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Drug Evaluation, Preclinical
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Lung / drug effects
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Lung / pathology
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Plasma Cell Granuloma, Pulmonary / chemically induced
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Plasma Cell Granuloma, Pulmonary / drug therapy*
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Plasma Cell Granuloma, Pulmonary / pathology
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Rats
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Rats, Wistar
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Time Factors
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beta Carotene / therapeutic use*
Substances
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Anti-Inflammatory Agents
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Dextrans
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beta Carotene
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sephadex
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Cromolyn Sodium