Abstract
Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Chromatography, High Pressure Liquid
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Crystallography, X-Ray
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Plants, Medicinal / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes