Infraspecific variation of sulfur-containing bisamides from Aglaia leptantha

J Nat Prod. 2000 May;63(5):616-20. doi: 10.1021/np990542y.

Abstract

Six new amides, leptaglin (1), hemileptaglin (2), aglanthin (3), agleptin (4), isoagleptin (5), and leptanthin (6), together with known lignans yangambin, eudesmin, grandisin (7), epigrandisin (8), and dehydrodiconiferyl alcohol, were isolated and identified from the lipophilic leaf and stem bark extracts of Aglaia leptantha. The dominating sulfur-containing bisamides contained either putrescine or the corresponding pyrrolidine ring as the diamine part, linked to phenylacetic and/or methylthiopropenoic acid moieties showing a remarkable infraspecific variation in eight individuals from two different habitats. Structures were determined by MS and NMR, including lanthanide-induced shifts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amides / isolation & purification
  • Antifungal Agents / pharmacology
  • Asia, Southeastern
  • Chromatography, Thin Layer
  • Cladosporium / drug effects
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry*
  • Species Specificity
  • Spectrophotometry, Ultraviolet
  • Sulfur Compounds / chemistry*
  • Sulfur Compounds / isolation & purification

Substances

  • Amides
  • Antifungal Agents
  • Plant Extracts
  • Sulfur Compounds