Antimycobacterial activity of ionic fullerene derivatives

Bioorg Med Chem Lett. 2000 May 15;10(10):1043-5. doi: 10.1016/s0960-894x(00)00159-1.

Abstract

Positively charged fullerene derivatives, moderately soluble in water:DMSO 9:1, have been tested using three strains of Mycobacterium spp. Some compounds inhibit the growth of Mycobacterium tuberculosis, a human clinical isolate, particularly virulent and resistant, at doses as low as 5 microg/mL.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Carbon / chemistry*
  • Carbon / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Mycobacterium / drug effects*
  • Mycobacterium avium / drug effects
  • Mycobacterium tuberculosis / drug effects
  • Pyrrolidines / chemistry*
  • Pyrrolidines / pharmacology*
  • Solubility
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Pyrrolidines
  • Carbon