Abstract
Various methodological approaches that can be used to detect ototoxic effects caused by the administration of various substances are presented, using the Sprague-Dawley rat as an animal model. Electrophysiological data are also presented to show how the model behaves with potentially ototoxic (hyaluronic acid) and initially inert (hydroxy-propyl-methyl-cellulose) substances.
MeSH terms
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Acoustic Stimulation
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Adjuvants, Immunologic / adverse effects*
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Animals
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Disease Models, Animal*
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Ear, Middle / drug effects*
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Ear, Middle / physiology
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Ear, Middle / ultrastructure
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Evoked Potentials, Auditory, Brain Stem / drug effects
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Evoked Potentials, Auditory, Brain Stem / physiology
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Hyaluronic Acid / adverse effects*
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Lactose / adverse effects
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Lactose / analogs & derivatives*
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Methylcellulose / adverse effects
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Methylcellulose / analogs & derivatives*
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Microscopy, Electron
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Mucous Membrane / drug effects
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Mucous Membrane / physiology
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Oxazines
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Rats
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Rats, Sprague-Dawley
Substances
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Adjuvants, Immunologic
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Oxazines
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Hyaluronic Acid
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Methylcellulose
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MK 458
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Lactose