Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

M Murakami; O Nakagawasai; S Fujii; M Hosono; S Hozumi; A Esashi; R Taniguchi; T Okamura; T Suzuki; H Sasano; T Yanagisawa; K Tan-no; T Tadano; K Kitamura; K Kisara

doi:10.1016/s0006-8993(00)02295-2

Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

Brain Res. 2000 Jun 16;868(1):123-7. doi: 10.1016/s0006-8993(00)02295-2.

Authors

M Murakami¹, O Nakagawasai, S Fujii, M Hosono, S Hozumi, A Esashi, R Taniguchi, T Okamura, T Suzuki, H Sasano, T Yanagisawa, K Tan-no, T Tadano, K Kitamura, K Kisara

Affiliation

¹ Department of Molecular Pharmacology, Tohoku University School of Medicine, Seiryomachi, Aobaku, 980-8575, Sendai, Japan. mmura@mail.cc.tohoku.ac.jp

PMID: 10841896
DOI: 10.1016/s0006-8993(00)02295-2

Abstract

We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcium Channel Blockers / pharmacology*
Calcium Channels, N-Type / genetics
Calcium Channels, N-Type / metabolism*
Dihydropyridines / pharmacology*
Dose-Response Relationship, Drug
Ganglia, Spinal / cytology
Ganglia, Spinal / drug effects
Gene Expression / physiology
In Situ Hybridization
Mice
Mice, Inbred C57BL
Nicardipine / pharmacology
Nociceptors / drug effects*
RNA, Messenger / analysis
Synaptic Transmission / drug effects

Substances

Calcium Channel Blockers
Calcium Channels, N-Type
Dihydropyridines
RNA, Messenger
cilnidipine
Nicardipine