Recurrent venous thrombosis in a patient with chronic lymphocytic leukemia and acquired protein S deficiency

P Miljić; N Milosević-Jovicić; P Antunović; D Bosković; N Basara; Z Rolović

doi:10.1163/15685590051129896

Recurrent venous thrombosis in a patient with chronic lymphocytic leukemia and acquired protein S deficiency

Haematologia (Budap). 2000;30(1):51-4. doi: 10.1163/15685590051129896.

Authors

P Miljić¹, N Milosević-Jovicić, P Antunović, D Bosković, N Basara, Z Rolović

Affiliation

¹ Institute of Haematology, University Clinical Center, Belgrade, Yugoslavia.

PMID: 10841326
DOI: 10.1163/15685590051129896

Abstract

A patient with chronic lymphocytic leukemia and an undetectable plasma level of protein S (PS), associated with recurrent venous thrombosis, is described. The laboratory investigation revealed the concomitant presence of an inhibitor directed to PS and a monoclonal protein in the patient's plasma. After treatment with prednisone and cyclophosphamide both the inhibitor to PS and the monoclonal component disappeared.

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cyclophosphamide / administration & dosage
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / blood
Leukemia, Lymphocytic, Chronic, B-Cell / complications*
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
Male
Middle Aged
Prednisone / administration & dosage
Protein S Deficiency / blood
Protein S Deficiency / etiology*
Recurrence
Venous Thrombosis / etiology*

Substances

Cyclophosphamide
Prednisone