A two-step total synthesis of the natural pentacycle trichodimerol, a novel inhibitor of TNF-alpha production

Org Lett. 1999 Nov 4;1(9):1503-4. doi: 10.1021/ol991070h.

Authors

D Barnes-Seeman¹, E J Corey

Affiliation

¹ Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts 02138, USA.

PMID: 10825998
DOI: 10.1021/ol991070h

Abstract

[formula: see text] Trichodimerol (1) can be synthesized by a remarkable dimerization of the chiral hydroxy dienone 5.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Bridged-Ring Compounds / chemical synthesis*
Bridged-Ring Compounds / chemistry
Dimerization
Molecular Structure
Spectrum Analysis
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Tumor Necrosis Factor-alpha / biosynthesis

Substances

Bridged-Ring Compounds
Tumor Necrosis Factor-alpha
trichodimerol