Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells

Acta Biochim Pol. 1999;46(4):967-70.

Abstract

Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gene Transfer Techniques
  • Genetic Therapy*
  • Genetic Vectors
  • Interleukin-10 / biosynthesis*
  • Interleukin-10 / genetics*
  • Interleukin-10 / therapeutic use
  • Melanoma, Experimental / genetics*
  • Melanoma, Experimental / immunology
  • Melanoma, Experimental / therapy*
  • Mice
  • Mice, Inbred C57BL
  • Neoplasm Transplantation
  • Tumor Cells, Cultured

Substances

  • Interleukin-10