Abstract
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Gene Transfer Techniques
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Genetic Therapy*
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Genetic Vectors
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Interleukin-10 / biosynthesis*
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Interleukin-10 / genetics*
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Interleukin-10 / therapeutic use
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Melanoma, Experimental / genetics*
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Melanoma, Experimental / immunology
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Melanoma, Experimental / therapy*
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Mice
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Mice, Inbred C57BL
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Neoplasm Transplantation
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Tumor Cells, Cultured