Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors

Microbes Infect. 2000 Apr;2(4):371-80. doi: 10.1016/s1286-4579(00)00330-0.

Abstract

HLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E demonstrates that the specificity of leader peptide binding is a structurally defined intrinsic property of HLA-E.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Antigens, CD / immunology*
  • Antigens, CD / metabolism
  • Cytotoxicity, Immunologic
  • HLA Antigens / chemistry
  • HLA Antigens / immunology*
  • HLA Antigens / metabolism
  • HLA-E Antigens
  • Histocompatibility Antigens Class I / chemistry
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class I / metabolism
  • Killer Cells, Natural / immunology*
  • Lectins, C-Type*
  • Membrane Glycoproteins / immunology*
  • Membrane Glycoproteins / metabolism
  • Mice
  • Models, Immunological
  • NK Cell Lectin-Like Receptor Subfamily C
  • NK Cell Lectin-Like Receptor Subfamily D
  • Protein Sorting Signals / metabolism
  • Receptors, Immunologic / immunology*
  • Receptors, Immunologic / metabolism
  • Receptors, Natural Killer Cell

Substances

  • Antigens, CD
  • HLA Antigens
  • Histocompatibility Antigens Class I
  • Klrc1 protein, mouse
  • Klrd1 protein, mouse
  • Lectins, C-Type
  • Membrane Glycoproteins
  • NK Cell Lectin-Like Receptor Subfamily C
  • NK Cell Lectin-Like Receptor Subfamily D
  • Protein Sorting Signals
  • Q surface antigens
  • Receptors, Immunologic
  • Receptors, Natural Killer Cell