Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population

H Iwasa; T Itoh; R Nagai; Y Nakamura; T Tanaka

doi:10.1007/s100380050207

Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population

J Hum Genet. 2000;45(3):182-3. doi: 10.1007/s100380050207.

Authors

H Iwasa¹, T Itoh, R Nagai, Y Nakamura, T Tanaka

Affiliation

¹ Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Japan.

PMID: 10807545
DOI: 10.1007/s100380050207

Abstract

We report here 20 single nucleotide polymorphisms (SNPs), including 10 novel ones, and their allelic frequencies detected in four genes that are known to be responsible for familial long QT syndrome in the Japanese population; 7 polymorphisms are in the KCNQ1 gene, 6 in the KCNH2 gene, 5 in the SCN5A gene, and 2 in the KCNE1 gene. These data will be of use for genetic association studies of acquired cardiac arrhythmias.

MeSH terms

Alleles*
Family Health
Gene Frequency*
Humans
Japan
Long QT Syndrome / genetics*
Polymorphism, Single Nucleotide*
Sequence Analysis, DNA