Abstract
In our continuous investigation for free radical scavengers from extracts of fruit body of basidiomycetes, we have isolated four new p-terphenyl compounds, designated as curtisians A-D, from the methanolic extract of the fruit body of Paxillus curtisii. These compounds were isolated by silica gel and Sephadex LH-20 column chromatographies, preparative-TLC and HPLC, consecutively. The structures of curtisians were assigned as p-terphenyls with substituents of acetyl, benzoyl, phenylbutyryl, 3-hydroxybutyryl and 3-acetoxybutyryl. Curtisians A, B, C and D exhibited inhibitory activity against lipid peroxidation with IC50, values of 0.15, 0.17, 0.24 and 0.14 microg/ml, respectively.
MeSH terms
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Agaricales / chemistry*
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Animals
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Bepridil / analogs & derivatives
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Bepridil / metabolism
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Biphenyl Compounds
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Free Radical Scavengers / chemistry*
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Free Radical Scavengers / isolation & purification
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Free Radical Scavengers / pharmacology*
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Free Radicals / metabolism
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Inhibitory Concentration 50
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Lipid Peroxidation / drug effects
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Magnetic Resonance Spectroscopy
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Microsomes, Liver / drug effects
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Microsomes, Liver / metabolism
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Molecular Structure
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Phenylacetates / chemistry*
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Phenylacetates / isolation & purification
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Phenylacetates / pharmacology*
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Picrates*
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Rats
Substances
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Biphenyl Compounds
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Free Radical Scavengers
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Free Radicals
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Phenylacetates
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Picrates
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curtisian A
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curtisian B
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curtisian C
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curtisian D
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Bepridil
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1,1-diphenyl-2-picrylhydrazyl