Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy

Neurology. 2000 May 9;54(9):1856-9. doi: 10.1212/wnl.54.9.1856.

Abstract

The authors enrolled 1,029 patients with CD4 counts </= 200/microL and no CNS AIDS-defining events (CNS-AIDS) between January 1993 and December 1998. The primary end point was the first appearance of CNS-AIDS. Three different periods and different antiretroviral regimens were considered. During the median follow-up of 329 days, 144 patients (9.5%) developed CNS-AIDS. The independent predictors were CD4 counts and therapy. All regimens decreased the risk of CNS-AIDS. Highly active antiretroviral therapy led to a 95% risk reduction in comparison with untreated patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Dementia Complex / diagnosis
  • AIDS Dementia Complex / drug therapy*
  • Adult
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use*
  • CD4 Lymphocyte Count
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • HIV Seropositivity / diagnosis
  • HIV Seropositivity / drug therapy*
  • Humans
  • Male
  • Risk Factors

Substances

  • Anti-HIV Agents